THE MIRACLE CHOCOLATE
The CHOCOLATE DR. SIMÓN FIT , more than a dessert without added sugar, is a complete food with unique medicinal properties. Rich in proteins of high biological value that contain essential amino acids and are especially rich in lysine and leucine, helping your body in the formation of tissues such as muscles, it has essential Omega 3 fatty acids with a powerful anti-inflammatory effect, the prebiotics in its composition they help to cultivate our intestinal flora with the correct bacteria and to produce short-chain fatty acids such as butyrate that stimulate our immune system and promote the death of cancer cells, its lauric acid content gives it unique antimicrobial properties, medium-chain triglycerides that possesses in abundance are a potent source of immediate energy. But besides being nutritionally rich my EL CHOCOLATE DR. SIMÓN FIT is special because it is loaded with Ganaderma lucidum spores of the highest quality. Ganoderma lucidum is an oriental mushroom that has a long history of use to promote health and longevity in China, Japan, and other Asian countries.
- Help lose weight
- Stop premature aging
- Boost your immune system
- Reduce anxiety attacks
- Increase energy levels
- Improve your mood
- Fight cancer cells
- Battling autoimmune diseases
- Reduces bad fats in the blood and protects arterial walls, helping to prevent heart attacks and cerebrovascular diseases
HISTORY OF THE ORIGIN OF GANODERMA
The Chinese often call it lingzhi, while in Japan the Ganodermataceae family name is Reishi or mannentake.
In Chinese, the name lingzhi represents a combination of spiritual power and essence of immortality, it is considered as the "herb of spiritual power" that symbolizes success, well-being, divine power and longevity. Among cultivated mushrooms, Ganoderma lucidum is unique for its pharmaceutical value. Specific applications and attributed health benefits include control of blood glucose levels, modulation of the immune system, hepatoprotection, bacteriostasis, and more. Initially, beliefs about the health benefits of the mushroom were supported by anecdotal evidence, traditional use, and cultural customs. However, recent reports provide scientific support for some of the longstanding claims of Ganoderma's health benefits.
Ganoderma has been recognized as a medicinal mushroom for over 2,000 years, and its powerful effects have been documented in ancient scripts (Wasser 2005). The proliferation of G. lucidum images in art began in AD 1400, and they are associated with Taoism (McMeekin 2005). However, images of G. lucidum spread beyond religion and appeared in paintings, sculptures, furniture, and even women's accessories (Wasser 2005). The first book devoted entirely to the description of herbs and their medicinal value was Shen Nong Ben Cao Jing, written in China's Eastern Han Dynasty (25-220 AD). This book is also known as “Classic of Materia Medica” or “Shen-nong Herbal Classics”. It describes botanical, zoological and mineral substances, and was composed in the second century under the pen name Shen-nong (“the holy farmer”; Zhu, 1998). The book, which has been continually updated and expanded, describes the beneficial effects of various mushrooms with a reference to the medicinal mushroom G. lucidum (Zhu, 1998; Upton 2000; Sanodiya et al. 2009). In the Supplement to the Classic of Materia Medica (502-536 AD) and Li Shin-Zhen's Ben Cao Gang Mu, which is considered the first pharmacopoeia in China (1590 AD; Ming Dynasty), the mushroom was attributed with therapeutic effects. properties, such as toning effects, improvement of vital energy, strengthening of cardiac function, memory enhancement and anti-aging effects. According to the State Pharmacopoeia of the People's Republic of China (2000), G. lucidum acts to replenish Qi, soothe the mind, and alleviate cough and asthma, and is recommended for dizziness, insomnia, palpitations, and shortness of breath.
Wild Ganoderma is rare, and in the years before its cultivation, only the nobility could afford it. The sacred mushroom was believed to grow in the home of the immortals in the “three halls of blessing” off the coast of China (McMeekin 2005).
WHY CHOCOLATE DR. DOES SIMÓN FIT HAVE SO MANY MEDICINAL PROPERTIES?
Because THE CHOCOLATE DR. SIMÓN FIT has a high concentration of organic extract of Ganoderma lucidum Of the highest quality, this extract contains a wide variety of bioactive molecules, such as terpenoids, steroids, phenols, nucleotides and their derivatives, glycoproteins and polysaccharides.
Ganoderma polysaccharides are reported to exhibit a wide range of bioactivities, including anti-inflammatory, hypoglycemic, antiulcer, antitumor, and immunostimulatory effects (Miyazaki and Nishijima 1981; Hikino et al. 1985; Tomoda et al. 1986; Bao et al. 2001; Wachtel-Galor, Buswell et al. 2004). Numerous refined polysaccharide preparations extracted from G. lucidum are now marketed as over-the-counter treatment for chronic diseases, including cancer and liver disease (Gao et al. 2005). The freeze-dried fruit bodies of Ganoderma spp. those collected from nature were reported to have a mineral content of 10.2%, with potassium, calcium and magnesium as main components (Chiu et al. 2000).
Some attention has been paid to the germanium content of Ganoderma spp. Germanium was the fifth highest in terms of concentration (489 μg/g) among the minerals detected in G. lucidum fruit bodies collected from the wild (Chiu et al. 2000). This mineral is also present in the order of parts per billion in many plant foods, including ginseng, aloe, and garlic (Mino et al. 1980). Although germanium is not an essential element, at low doses, immunopotentiating, antitumor, antioxidant, and antimutagenic activity has been attributed to it (Kolesnikova, Tuzova, and Kozlov 1997).
Other compounds that have been isolated from G lucidum they include enzymes such as metalloprotease, which delays clotting time; ergosterol (provitamin D2); nucleosides; and nucleotides (adenosine and guanosine; Wasser 2005; Paterson 2006). Kim and Nho (2004) also described the isolation and physicochemical properties of a highly specific and effective reversible inhibitor of α-glucosidase, SKG-3, from the fruit bodies of G. lucidum . In addition, it was reported that the spores of G lucidum they contained a mixture of various long-chain fatty acids that may contribute to the antitumor activity of the fungus (Fukuzawa et al. 2008).
ANTIVIRAL AND ANTIBACTERIAL CAPACITY
The goal of research in the treatment of viral and bacterial infections is the discovery of agents that specifically inhibit viral and bacterial replication without affecting normal cells. The unwanted side effects of antibiotics and antivirals and the emergence of resistant strains and mutants make the development of new agents an urgent requirement. This has led researchers to investigate the antibacterial and antiviral activity of medicinal plants and mushrooms (Wasser and Weis 1999; Zhong and Xiao 2009). The isolation of several high molecular weight PBPs soluble in water and methanol from G lucidum showed inhibitory effects on herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2) and New Jersey strain vesicular stomatitis virus (VSV) in a tissue culture system . Using the plaque reduction method, a significant inhibitory effect was observed at doses that did not show cytotoxicity (Eo et al. 1999; Oh et al. 2000). In addition, there was a marked synergistic effect when PBP was used from G lucidum in tissue culture together with antiherpetic agents, aciclovir or vidarabine, and with IFN-α (Kim et al. 2000; Oh et al. 2000). Similar results were shown in HSV-1 and HSV-2 with a GLPG isolated from G. lucidum mycelium (Liu et al. 2004; Li, Liu and Zhao 2005). Cells were treated before, during and after infection, and the viral titer in the cell culture supernatant was determined 48 hours after infection. The antiviral effects of GLPG were more noticeable before viral treatment than after treatment. Although the mechanism was not defined, the authors concluded that GLPG inhibits viral replication by interfering with early viral adsorption events (Li, Liu, and Zhao 2005).
It has also been reported that some triterpenes from G lucidum have an inhibitory effect against human immunodeficiency virus (HIV)-1 protease activity, with IC50 values ranging from 20 to more than 1000 μM; however, not all triterpenes examined showed anti-HIV activity (El-Mekkawy et al. 1998; Min et al. 1998). In another study, a ganoderic acid isolated from G. lucidum showed inhibitory effects on hepatitis B virus (HBV) replication in HepG2215 cells (HepG2-HBV-producing cell line) for 8 days. Production of HBV surface antigen (HBsAg) and HBV e antigen (HBeAg) was respectively 20% and 44% of controls without ganoderic acid treatment (Li and Wang 2006).
Some small studies in human patients have also reported beneficial effects of lingzhi intake. An oral hot water dry extract of G. lucidum (equivalent to 36 or 72 g of dried mushrooms per day) was used as the sole treatment for postherpetic neuralgia (varicella zoster virus) in 4 elderly patients. This treatment has been reported to dramatically decrease pain and promote lesion healing, without any toxicity even at very high doses (Hijikata and Yamada 1998). In another study, a mixture of G lucidum with other herbs improved recovery time in patients with genital herpes (n=15) and cold sores (n=13; Hijikata, Yamada, and Yasuhara 2007).
To evaluate the antibacterial effects of the fungus, several in vitro and in vivo animal studies were performed using G. lucidum . Mice injected with extract of G lucidum (2 mg/mouse) 1 day before injection with Escherichia coli showed markedly improved survival rates (>80% compared to 33% in controls; Ohno et al. 1998). In an in vitro study using the disk assay (Keypour et al. 2008), a chloroform extract of G lucidum for its antibacterial effect on gram positive bacteria (Bacillus subtilis, Staphylococcus aureus, Enterococcus faecalis) and gram negative bacteria (E. coli, Pseudomonas aeruginosa). The results showed that the extract had growth inhibitory effects on two of the gram-positive bacteria with a minimum inhibitory concentration (MIC) of 8 mg/ml for S. aureus and B. subtilis . In another in vitro study, the direct antimicrobial effect of an extract of water from G lucidum against 15 species of bacteria alone and in combination with 4 types of antibiotics (Yoon et al. 1994). It was discovered that G lucidum was more effective than antibiotics against E. coli, Micrococcus luteus, S. aureus, B. cereus, Proteus vulgaris, and Salmonella typhi , but less effective against other species tested. The antimicrobial combination of G lucidum with four commonly used antibiotics (Yoon et al. 1994) resulted in an additive or synergistic effect in most but not all cases, with apparent antagonism against the effects of cefazolin and ampicillin on P. vulgaris.
BOOSTS THE IMMUNE SYSTEM
Agents that enhance the functioning of the host's immune system might be expected to improve health in terms of better resistance and thus elimination of malignant or pre-malignant cells. There is considerable evidence to support the immunostimulatory activities of G lucidum through cytokine induction and immunological effector enhancement (Wang et al. 1997; Zhu and Lin 2006). It was shown that different components of G lucidum increase the proliferation and maturation of T and B lymphocytes, splenic mononuclear cells, NK cells, and dendritic cells in in vitro culture and in vivo animal studies (Bao et al. 2001; Cao and Lin 2002; Zhu, Chen, and Lin 2007; Ma et al. 2008). A polysaccharide fraction (F3) was shown to enhance adaptive and innate immunities by triggering the production of the cytokines IL-1, IL-6, IL-12, IFN-γ, TNF-α, and colony-stimulating factors (CSF) from the mouse splenocytes (Chen et al. 2004). It was also reported that TNF-α and IL-6 production was stimulated in human and murine macrophages by G lucidum mycelia (Kuo et al. 2006). This effect could be due to an increased synthesis of nitric oxide (NO) induced by β-D-glucan (Ohno et al. 1998). These polysaccharides were also found to be highly suppressive of tumor cell proliferation in vivo while enhancing the host's immune response (Ooi and Liu 2000).
Wang et al. (1997) found that a fraction enriched with polysaccharides of G lucidum activated cultured T-lymphocytes and macrophages in vitro, leading to an increase in IL-1β, TNF-α, and IL-6 in the culture medium. In another study (Zhang and Lin 1999), incubation of macrophages and T lymphocytes with a polysaccharide resulted in increased levels of TNF-α and INF-γ in the culture medium. This "conditioned" culture medium was found to inhibit cell growth and induce apoptosis in sarcoma 180 and HL-60 cells (Zhang and Lin 1999). In addition, treatment with serum incorporated with a G. lucidum polysaccharide peptide fraction markedly inhibited human lung carcinoma (PG) cell proliferation, whereas the pure fraction alone did not induce similar effects (Cao and Lin 2004). . In addition to polysaccharides, a lanostane triterpenoid, ganoderic acid Me, inhibited tumor growth and metastasis of Lewis lung carcinoma in C57BL/6 “T helper 1 responder” mice by enhancing immune function in terms of IL-2 expression and IFN-γ and NK cell activity (Wang et al. 2007). Zhu and Lin (2006) used cytokine-induced killer (CIK) cells to investigate the interaction.
HIGHLIGHTED HUMAN STUDIES
G lucidum it is one of eight components of an herbal mixture called “prostate cancer hope” (known as PC-SEPS), which has been used as an alternative in the treatment of androgen-dependent and independent prostate cancer (Gao and Zhou 2009). . However, only a few trials clinicians have used G lucidum as a single agent in cancer patients (Gao, Zhou et al. 2002; Gao, Zhou et al. 2003; Gao, Sai et al. 2003). Two randomized controlled trials were conducted using an extract rich in GL-PS (an over-the-counter proprietary product, Ganopoly; Gao et al. 2003; Gao and Sai et al. 2003). Gao, Zhou et al. (2003) recruited 134 patients with advanced cancers from different sites and supplemented them with G. lucidum. at a dose of 1800 mg / day for 12 weeks. Cellular immunity in 80% of these patients was significantly increased in terms of elevated plasma interleukin (IL)-2, IL-6, and interferon-γ (IFN-γ) levels and natural killer (NK) cell activity. In another study, the same protocol was followed with 68 lung cancer patients (Gao, Sai et al. 2003) in which immune parameters, including total T cells, NK cells, and CD4/CD8 ratio, were significantly improved. in treatment with G lucidum cluster. In addition, the quality of life in terms of the Karnofsky score was improved in approximately 65% of these patients (Gao, Sai et al. 2003). Ganopoly was also shown to enhance mitogenic activity and NK cells in patients with advanced cancer in a before-and-after comparison study (Gao, Min et al. 2002). These results provide some evidence that the antitumor effects of G. lucidum are mediated by effects on the immune system.
Consuming antioxidant-rich plants may help prevent cancer and other chronic diseases (Collins 2005; Benzie and Wachtel-Galor 2009). Antioxidants protect cellular components from oxidative damage, which is likely to decrease the risk of mutations and carcinogenesis, and also protect immune cells, allowing them to maintain immune surveillance and response. various components of G. lucidum , particularly polysaccharides and triterpenoids, show antioxidant activity in vitro (Lee et al. 2001; Mau, Lin, and Chen 2002; Shi et al. 2002; Wachtel-Galor, Choi, and Benzie 2005; Yuen and Gohel 2008; Saltarelli et al.2009, Wu and Wang 2009). As shown in Figure 9.4, it was found that antioxidants from G. lucidum they are rapidly absorbed after ingestion, resulting in increased total antioxidant activity in plasma from human subjects (Figure 9.4; Wachtel-Galor, Szeto et al. 2004).
Ooi and Liu (2000) reported that protein-bound polysaccharide (PBP) and peptide polysaccharide were able to mimic the endogenous antioxidant superoxide dismutase (SOD) in cancer-bearing animals in vivo. These polysaccharides have also been reported to protect immune cells from oxidative damage (Ooi and Lui 2000). The protective effects of G. lucidum on DNA strand excision induced by a metal-catalyzed Fenton reaction, ultraviolet irradiation, and hydroxyl radical attack were shown on agarose gel electrophoresis in vitro (Lee et al. 2001). The hot water extracts of G lucidum significantly protected Raji cells from DNA damage induced by hydrogen peroxide (H2O2) (Shi et al. 2002). Hot water extracts protected human lymphocyte DNA only at low concentrations (<.001% w/v) and caused H2O2-mediated damage at higher concentrations (>.01% w/v) (Wachtel-Galor, Choi & Benzie 2005). Two antioxidant-enriched extracts of G. lucidum acted oppositely on premalignant HUC-PC cells under carcinogenic attack (Yuen and Gohel 2008). The aqueous extract protected cellular DNA from oxidative damage, while the ethanolic extract damaged cellular DNA, with increased H2O2 production and significant cell-killing effects observed. The results suggested that different extractable components in bladder chemoprevention might show different effects of G. lucidum . It was reported that methanol extracts of G lucidum prevent kidney damage (induced by the cancer drug cisplatin) by restoring the renal antioxidant defense system (Sheena, Ajith and Janardhanan 2003). In contrast, a fraction of ganoderma triterpenes (GTS) was found to enhance the doxorubicin (DOX)-producing effect in Hela cells, which results in further DNA damage and apoptosis, whereas such synergy was inhibited by Scavenger ROS ( Yue et al. 2008). In an animal study (diabetic rats), enzymatic and non-enzymatic antioxidant levels were increased and lipid peroxidation levels were decreased with treatment with G lucidum (Jia et al. 2009).
POWERFUL AGAINST DIABETES
It has been shown that the components of G lucidum have a hypoglycemic effect in animals. Administration of ganoderans A and B (100 mg/kg dose), two polysaccharides isolated from fruit body water extracts, by ip injection into normal and alloxane-induced diabetic mice significantly (up to 50%) decreased the plasma glucose concentrations, and the hypoglycemic effect was still evident after 24 hours (Hikino et al. 1985). Using a mouse model, ganoderan B has also been reported to increase plasma insulin, decrease liver glycogen content, and modulate the activity of glucose-metabolizing enzymes in the liver (Hikino et al. 1989). The same group reported that a third polysaccharide (ganoderan C) isolated from G lucidum it also showed significant hypoglycemic effects in mice, and that ganoderan B increased plasma insulin levels in normal and glucose-loaded mice (Hikino et al. 1989; Tomoda et al. 1986).
In a more recent study, it was found that oral administration of hot water extract of G lucidum (0.03 and 0.3 g/kg BW) for 4 weeks reduces serum glucose levels in obese/diabetic mice (+db/+db), with effects seen after the first week of treatment (Seto et al. 2009). However, glucose levels were still higher in these animals than in control animals, and insulin levels were not altered. The extract markedly reduced phosphoenol-pyruvate carboxykinase (PEPCK) levels, which are typically high in obese/diabetic mice. The suggested mechanism, according to the authors, is to reduce serum glucose levels through suppression of hepatic expression of the PEPCK gene. In another study (Jia et al. 2009), an extract rich in polysaccharides showed beneficial effects in streptozotocin-induced diabetic rats. Diabetic rats were treated with G lucidum for 30 days. After treatment, serum insulin levels increased (compared to the untreated diabetic group) and glucose levels decreased in a dose-dependent manner. Streptozotocin treatment also elevated levels of lipid peroxidation markers (thiobarbituric acid reactive substances [TBARS]), lipid hydroperoxides, and conjugated dienes); decreased levels of non-enzymatic antioxidants (vitamin C, reduced glutathione [GSH] vitamin E); and decreased activities of the antioxidant enzymes, SOD, catalase, and glutathione peroxidase (Gpx). After GL-PS treatment, enzymatic and non-enzymatic antioxidant levels increased and lipid peroxidation levels decreased. Therefore, in addition to its glycemic modulation, treatment with G lucidum helped decrease oxidative stress (Jia et al. 2009).
In a study published in the literature, 71 adult patients with confirmed type 2 diabetes mellitus (DM) were supplemented with Ganopoly (polysaccharide fractions extracted from G. lucidum ). Patients received Ganopoly or placebo orally at 1800 mg three times daily for 12 weeks. Glycosylated hemoglobin (HbA1C) and plasma glucose decreased significantly after 12 weeks, indicating a hypoglycemic effect of the extract (Gao, Lan et al. 2004). In general, the data from different studies suggest that the intake of G lucidum Helps modulate blood glucose levels.
PROTECT YOUR LIVER
It was found that hot water and water ether extracts from the fruit body of G lucidum have a potent hepatoprotective effect on liver injury induced by carbon tetrachloride (CCl4) administered orally and intraperitoneally to rats (Lin et al. 1995; Kim et al. 1999). Measured markers for liver injury included aspartate and alanine transaminases (AST and ALT) and lactate dehydrogenase (LDH). An active compound was separated from the extract and identified as ganoderenic acid A. It was found to have a potent inhibitory effect on β-glucuronidase, and the authors suggest that this inhibitory effect may have mediated the hepatoprotection observed when this isolated compound was administered ( Kim et al., 1999). Protection was also reported in a study in which a hot water extract of G lucidum orally to mice 30 min before ethanol administration. The extract was found to have an inhibitory effect against the formation of malondialdehyde (MDA), a breakdown product of lipid peroxides, in mouse liver and kidney homogenate, with evidence of a dose response (Shieh et al. 2001). The MDA effect was also reported by Shi et al. (2008) when the extract was administered orally to mice (at 60, 120, and 180 mg/kg/day) for 2 weeks prior to D-galactosamine treatment, it induced liver damage. Furthermore, pretreatment with G lucidum maintained normal AST, ALT, SOD, and GSH values (Shi et al. 2008). Alcohol and CCl4 toxicity is associated with increased oxidative stress and free radical-associated injury. Therefore, hepatoprotection may also be mediated by the radical scavenging properties of G. lucidum. Lin et al. (1995) reported that hot water extracts from G lucidum showed significant radical scavenging activity against superoxide and hydroxyl radicals.
In addition, it was reported that the methanolic extract of G lucidum showed liver protection. The extract was administered orally to rats (500 mg/kg/day) for 30 days before benzo(a)pyrene caused liver damage (Lakshmi et al. 2006). The extract prevented the increase in serum AST, ALT, and alkaline phosphatase (ALP) activities that result from benzo(a)pyrene challenge, and improved GSH, SOD, GpX, CAT, and glutathione S-transferase (GST) levels. . Protection from CCl4-induced liver injury was also observed in mice treated with ganoderic acid (from G. lucidum) at 10 mg and 30 mg/kg/day given by intravenous injection for 7 days (Li and Wang 2006). It was also shown that the medium in which it grew G lucidum has liver protective effects in an animal study of CCl4-induced liver damage (Liu et al. 1998).
It was found that polysaccharides extracted from G lucidum and administered orally to rats for 28 days ameliorate cirrhosis induced by biliary ligation (Park et al. 1997). In addition, the collagen content (as measured by hydroxyproline) in the rat liver was reduced and better liver morphology was found compared to control animals. Treatment significantly decreased ligation-induced increases in serum biochemical markers of liver damage (AST, ALT, ALP, and total bilirubin). Similar results were observed in a study by Wu, Fang, and Lin (2010) which found decreased hepatic hydroxyproline content and improved liver histology in mice. In this study, administration of thioacetamide (TAA) induced liver fibrosis for 12 weeks, followed by 4 weeks of treatment with extract of G lucidum (0.5 and 1.0 g/kg/day, by oral administration). The RT-QPCR analysis showed the treatment of the extract decreased the expression of mRNA of collagen (α1), actin α of the smooth muscle and the enzymes metalloproteinase-1 and metalloproteinase-13. Furthermore, the TAA-induced decrease in total collagenase activity was reversed by extract treatment, indicating that G lucidum protect again.
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